Longevity Supplements: Scientific Review

LongevityClinics Team13.06.2026

Longevity Supplements: Scientific Review

Which supplements actually work for extending healthy lifespan?

Top Supplements by Evidence

#### NMN (Nicotinamide Mononucleotide)

**Dose**: 250-1000mg daily

**Evidence**: Raises NAD+, improves metabolic health

**Cost**: $30-60/month

#### Resveratrol

**Dose**: 150-500mg daily

**Evidence**: Activates sirtuins, anti-inflammatory

**Cost**: $15-30/month

#### Metformin

**Dose**: 500-1500mg daily (prescription)

**Evidence**: Reduces aging markers

**Cost**: $10-30/month

#### Rapamycin

**Dose**: 3-6mg weekly (prescription)

**Evidence**: Extends lifespan in animals

**Cost**: $50-100/month

Supportive Supplements

**Vitamin D3**: 2000-5000 IU daily

**Omega-3**: 2-3g daily

**Magnesium**: 200-400mg daily

**CoQ10**: 100-200mg daily

Important Considerations

1. Consult doctor before starting

2. Quality matters (third-party tested)

3. Supplements complement lifestyle

4. Individual response varies

Key Takeaways

1. NMN has strongest evidence among supplements

2. Prescription options (metformin, rapamycin) show promise

3. Basic supplements are foundational

4. Lifestyle factors remain most important

Longevity Supplements: Scientific Review